Pharmacology Neuro

51 flashcards · Other · by Jared Blackwell

1. Lidocaine

   Local Anesthetic Blocks voltage-gated sodium channels. Medium acting *Systemic dose may block respiration, cardio, smooth muscle. -Amide Bupivicaine

2. Cocaine

   Local Anesthetic Blocks VGNa+C. Blocks reuptake of DA, NE, vasoconstriction. Medium acting *Respiratory, cardio, smooth muscle depression. -Ester Procaine, Benzocaine *Can cause allergic rxn via PABA formation.

3. Fluphenazine

   Anti-psychotic-Typical DA antagonist Malignant hyperthermia Extra-pyramidal movements *Increase prolactin-> lactation.

4. Haloperidol

   Anti-psychotic-Typical DA antagonist Malignant hyperthermia Extra-pyramidal movements *Increase prolactin-> lactation. Also used for Huntington's

5. Clozapine

   Anti-psychotic-Atypical DA antagonist CV issues *Increase prolactin-> lactation. Also for Huntington's

6. Risperidone

   Anti-psychotic-Atypical DA antagonist CV issues *Increase prolactin-> lactation. Also for Huntington's

7. Aripiprazole

   Anti-psychotic-Atypical DA antagonist CV issues *Increase prolactin-> lactation.

8. Donepezil

   Alzheimer's AChesterase Inhibitor

9. Rivastigmine

   Alzheimer's AChesterase Inhibitor

10. Memantine

    Alzheimer's Glutamate NMDA antagonist.

11. Carbamazepine

    Epilepsy Inactivation Na+ channel Teratogen Also mood stabilzer.

12. Phenytoin

    Epilepsy Inactivation Na+ channel Teratogen

13. Lamotrigine

    Epilepsy Inactivation Na+ channel SJS Also mood stabilzer.

14. Topiramte

    Epilepsy Inactivation Na+ channel Teratogen Also prophylactic migraine.

15. Valproic Acid

    Epilepsy Inactivation Na+ channel Teratogen Also mood stabilzer.

16. Zonisamide

    Epilepsy Inactivation Na+ channel Teratogen

17. Lacosamide

    Epilepsy Inactivation SLOW Na+ channel

18. Clonazepam

    Generalize seizures, anti-anxiety Benzo, increases the frequency of GABAa channel open.

19. Vigabatrin & Pentobarbital

    Generalize seizures, IV anesthetic Barbituates, increase duration of GABAa channel open.

20. Ethosuximade

    Epilepsy Voltage gated Ca2+ Antagonist.

21. Zonisamide

    Epilepsy Voltage gated Ca2+ Antagonist.

22. Levetiracetam

    Epilepsy Inhibit Vesicular Release -Brivaracetam, Levetiracetam

23. Felbamate

    Epilepsy Glutamate NMDA Antagonist. Aplastic anemia, liver failure.

24. Perampanel

    Epilepsy AMPA Antagonist Psychosis

25. Carbidopa/Levodopa

    Parkinson's Dopamine precursor *Carbidopa is added to levodopa since it inhibits the breakdown by enzymes in the GI tract.

26. Bromocriptine

    Parkinson's Dopamine agonist.

27. Amantadine

    Parkinson's Dopamine agonist.

28. Ropinirole

    Parkinson's Dopamine agonist.

29. Pramipexole

    Parkinson's Dopamine agonist.

30. Tolcapone

    Parkinson's COMT Inhbitor

31. Selegiline

    Parkinson's MAOI

32. Trihexyphenidyl & Benztropine Mesylate

    Parkinson's Muscarnic Antagonist

33. Desflurane

    Anesthetic Halogenated Gases Airway Irritation. (Also Isoflurane) Malignant hyperthemia

34. Isoflurane

    Anesthetic Halogenated Gases Airway Irritation. (Also Desflurane) Malignant hyperthemia

35. Enflurane

    Anesthetic Halogenated Gases Malignant hyperthemia

36. Sevoflurane

    Anesthetic Halogenated Gases Increase ICP. Malignant hyperthemia

37. Propofol

    Anesthetic IV adminsitration Enhance GABA at channel.

38. Thiopental

    Anesthetic IV adminsitration Barbituate increase duration of GABAa open.

39. Pentobaribtol

    Anesthetic (also seizures) IV adminsitration Barbituate increase duration of GABAa open.

40. Etomidate

    Anesthetic IV adminsitration DOES NOT decrease cardiac output.

41. Ketamine

    Anesthetic IV adminsitration Increase ICP (NO, Ketamine, Sevoflurane ALL increase ICP). Has analgesia affect.

42. Tetrabenazine

    Huntington's VMAT inhibitor, inhibits DA uptake to vesicles. Neuroleptic Malignant syndrome. -Risperidone, Clozapine, Haloperidol anti-psychotics also for Huntington's

43. Deutetrabenazine

    Huntington's VMAT inhibitor, inhibits DA uptake to vesicles. Neuroleptic Malignant syndrome. -Risperidone, Clozapine, Haloperidol anti-psychotics also for Huntington's

44. Fluoxetine

    Huntington's, also depression/OCD SSRI Sexual & GI disturbances (Prozac)

45. Timolol

    Ocular HTN B2 antagnoist

46. Brimonidine

    Ocular HTN Alpha 2 agonist Decrease Synthesis

47. Apraclonidine

    Ocular HTN Alpha 2 agonist Decrease Synthesis

48. Acetazolamide

    Ocular HTN CA Inhibitor Decrease Synthesis

49. Pilcarpine

    Ocular HTN Muscarnic agonist Increase outflow

50. Latanoprost

    Ocular HTN Prostaglandin receptor agonist. Increase outflow.

51. Physostigmine

    Ocular HTN AChesterase inhibitor Increase outflow