Chapter 14: Responses to Radiotherapy: Tumour Control, Normal Tissue Damage

9 flashcards · Biology · by Kristóf Nagy

1. Parallel organ

   An organ whose function depends on the function of a certain number of FSUs. The organ can tolerate the loss of some FSUs without losing function.3349505356

2. Mixed organ

   An organ with a combination of serial and parallel FSUs.48

3. Serial organ

   An organ whose function depends on the integrity of all its FSUs. If one FSU is damaged, the entire organ fails.4849

4. Functional Sub-Unit (FSU)

   A theoretical concept in radiobiology that represents the smallest unit of tissue that can function independently.27334546...

5. Normal tissue complication probability (NTCP)

   The probability of radiation-induced damage to normal tissues.18193641...

6. Sigmoid curve

   A mathematical function that describes the relationship between dose and response in radiobiology, often used to model TCP and NTCP.4350

7. Epidemiology

   The study of the distribution and determinants of health-related states or events in specified populations, used in radiobiology to study the incidence of radiation-induced complications.4344

8. Tumour control probability (TCP)

   The probability that a given course of radiotherapy will eradicate all tumour cells.183336

9. Multivariable logistic regression

   A statistical method used to model the probability of a binary outcome (such as the occurrence of a complication) based on multiple predictor variables.4457