IM：風濕免疫

25 flashcards · Other · by Wanying Koh

1. SLE: monitor disease activity use which autoimmune markers?

   anti-dsDNA, C3, C4

2. immunosuppressant with AE of DM

   tacrolimus

3. inc. aPTT + DVT what disease what marker

   antiphospholipid syndrome lupus anticoagulant (prothrombotic AB)

4. protein C / S function

   anticoagulant, prevent blood from clotting too much

5. cyclosporine-A AE

   neurotoxicity nephrotoxicity HTN hyperlipidemia (hyperglycemia: tacrolimus)

6. marker with highest possibility for diagnosis in SLE

   ANA (in 90-95% of pts)

7. anti-cyclic citrullinated peptide AB (anti-CCP AB) present in ?

   rhematoid arthritis

8. SLE tx

   non-life threatening: NSAID hydroxychloroquine low dose steroid life threatening: induction: high dose steroid + cyclophosphamide / MMF maintenance: cyclophosphamide switch to MMF/ azathioprine

9. RA tx

   NSAID steroid DMARDs: MTX, leflunomide, sulfasalazine, hydrochloroquine biological agents: rituximab, anti-TNF (etanercept, adalimumab) immunosuppressants: cyclophosphamide, azathioprine

10. morning stiffness in RA duration

    > 1hr

11. markers present in sjogren syndrome

    anti-SS-A (Ro) / anti-SS-B (La) AB ANA rheumatoid factors (常合併 RA)

12. most common malignancy associated w Sjogren syndrome

    non-Hodgkin lymphoma

13. Systemic scleroderma patho

    Vasculopathy: Raynaud's phenomenon cause bv walls to 發炎, fibrosis Fibrosis: Th2 cells produce TGFb, induce fibroblasts to cause fibrosis

14. polymyositis dx

    肌電圖 muscle biopsy anti-Jo-1 AB / anti-histidyl tRNA synthetase AB

15. mixed connective tissue dz marker

    anti-U1 RNP

16. vasculitis: immune complex deposition in bv walls associated with what dz

    henoch schonlein purpura polyneuritis nodosa (HBV) cryoglobulinemia (HCV) Behcet's dz

17. Wegner's granulomatosis marker? targeting what ?

    c-ANCA targeting proteinase-3 (antiproteinase-3 AB)

18. DIP pain in what arthritis

    psoriatic arthritis osteoarthritis (RA 無)

19. male, lumbar pain, morning stiffness for >30min, x-ray no radiographic changes dx?

    axial spondyloarthropathy not ankylosing spondylitis (radiographic changes)

20. eye manifestations in: rheumatoid arthritis AS PsA behcet's

    scleritis unilateral acute, anterior uveitis (AAA) bilateral chronic posterior uveitis panuveitis

21. psoriatic arthritis radiographic findings 通常影響哪裡

    joint space narrowing marginal erosions juxta-articular osteoporosis pencil in cup deformity @ hands, feet. SIJ, spine. 少 knee, ankle, elbow (無 osteophyte)

22. Dx and features? involvement of single or multiple joint which joints involved most common tendon

    calcified tendon + tendon 發炎 --> hydroxyapatite deposition disease usually single joint shoulder, hip joints most common at supraspinatus

23. arthritis 分類 involvement of monoarticular / polyarticular: infection trauma tuberculosis viral sarcoidosis gout degenerative 退化性

    acute monoarticular acute monoarticular chronic monoarticular acute polyarticular autoimmune --> chronic polyarticular acute monocular monocular

24. pseudogout findings on xray

    線狀鈣化 = chondrocalcinosis (cartilage calcification)

25. chondrocalcinosis - seen in osteoarthritis, pseudogout