IM：腫瘤科

24 flashcards · Other · by Wanying Koh

1. colon cancer first line chemotherapy regimen

   FOLFOX: Leucovorin (FOL) + 5FU + Oxaliplatin

2. breast ca first-line hormonal therapy 停經前 藥物 停經後 藥物

   前：tamoxifen 後：aromatase inhibitor: anastrozole, letrozole, exemestane

3. s/s of colorectal cancer in each part of colon: ascending colon descending colon rectal cancer

   A: IDA, weight loss (晚發現) D: intestinal obstruction, 大便習慣改變 R: 裏急後重

4. Hodgkin lymphoma associated w what virus

   EBV

5. Kaposi's sarcoma associated w what virus

   HHV-8

6. mediastinal tumor + LDH/AFP/B-hCG 都高 + no testis tumor 選項 Dx

   non-seminomatous germ cell tumor (seminomatous: LB // no AFP inc. in pure seminoma non-seminomatous: AB)

7. HPV most commonly associated w what cancer

   oropharyngeal ca

8. AFP doesnt increase in which: teratocarcinoma hepatic adenoma HCC severe viral hepatitis

   hepatic adenoma (teratoca --> non-seminoma)

9. cisplatin causes what ion abnormalities

   low Ca, low Mg

10. doxorubicin AE

    cardiac toxicity BM suppression N/V (no renal toxicity)

11. cyclophosphamide AE

    hemorrhagic cystitis BM suppression N/V (no neuropathy)

12. 40y/o F w non-tender hard mass in L breast, irregular borders, non-movable diagnostic tool?

    40y/o --> mammography 因符合 BIRADS 4, 5 --> biopsy

13. Li-Fraumeni syndrome involves what malignancies

    BLAST53 breast / brain ca (glioblastoma) lymphoma / leukemia adrenocortical ca sarcoma tp53 gene AD mutation

14. HNPCC involves what malignancies

    = Lynch syndrome endometrial ca colon ca ovarian ca gastric ca pancreatic ca urothelial ca

15. immunochemical stool occult test 會不會測到 upper GI bleeding? need any food restrictions? (results affected by food?)

    NO. not affected by e.g. nose bleeding / upper GI bleeding NO.

16. positive stool occult test next step of dx?

    confirm by colonoscopy

17. HNPCC gene mutations

    germline mutation of hMSH2 gene

18. clinical manifestations of carcinoid tumor

    diarrhea (NOT constipation) asthma pellagra hot flushes

19. erythrocytosis associated w what malignancies

    HCC , RCC, cerebellar hemangioblastoma (NOT lymphoma)

20. ion abnormalities of tumor lysis syndrome

    high K high PO ----> bind to Ca ----> low Ca uric acid inc ---> pH of blood acidic

21. tumor lysis syndrome cause

    rapidly growing tumor 又大 又快 (high cell turnover rate, rapid growth rate, high tumor bulk) after chemotherapy ----> 因而造成 massive release of cell contents into blood

22. cachexia tx

23. tumor marker LDH used in what cancer

    non-hodgkin lymphoma, seminoma, acute leukemia

24. BCL-ABL EGFR HER2 VEGF

    CMl colorectal ca breast ca RCC